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Which of the following statements is true regarding DNA replication?Choose 1 answer:Choose 1 answer:(Choice A)   During lagging strand synthesis, ligase joins together multiple Okazaki fragments.ADuring lagging strand synthesis, ligase joins together multiple Okazaki fragments.(Choice B)   During leading strand synthesis, DNA polymerase synthesizes short, discontinuous strands of DNA.BDuring leading strand synthesis, DNA polymerase synthesizes short, discontinuous strands of DNA.(Choice C)   During lagging strand synthesis, topoisomerase separates complementary strands of DNA.CDuring lagging strand synthesis, topoisomerase separates complementary strands of DNA.(Choice D)   During leading strand synthesis, a DNA primer helps initiate DNA synthesis.DDuring leading strand synthesis, a DNA primer helps initiate DNA synthesis.

Question

Which of the following statements is true regarding DNA replication?Choose 1 answer:Choose 1 answer:(Choice A)   During lagging strand synthesis, ligase joins together multiple Okazaki fragments.ADuring lagging strand synthesis, ligase joins together multiple Okazaki fragments.(Choice B)   During leading strand synthesis, DNA polymerase synthesizes short, discontinuous strands of DNA.BDuring leading strand synthesis, DNA polymerase synthesizes short, discontinuous strands of DNA.(Choice C)   During lagging strand synthesis, topoisomerase separates complementary strands of DNA.CDuring lagging strand synthesis, topoisomerase separates complementary strands of DNA.(Choice D)   During leading strand synthesis, a DNA primer helps initiate DNA synthesis.DDuring leading strand synthesis, a DNA primer helps initiate DNA synthesis.

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Solution

The correct answer is (Choice A) During lagging strand synthesis, ligase joins together multiple Okazaki fragments.

Here's why:

During DNA replication, the DNA molecule is unzipped into two strands - the leading strand and the lagging strand.

The leading strand is synthesized continuously in the 5' to 3' direction by DNA polymerase.

The lagging strand, on the other hand, is synthesized discontinuously in the form of short fragments known as Okazaki fragments. These fragments are then joined together by an enzyme called DNA ligase to form a continuous strand.

Therefore, statement A is correct.

The other statements are incorrect because:

B) During leading strand synthesis, DNA polymerase synthesizes a continuous strand of DNA, not short, discontinuous strands.

C) Topoisomerase does not separate complementary strands of DNA during lagging strand synthesis. Its role is to relieve strain in the double helix ahead of the replication fork.

D) While it's true that a primer is needed to initiate DNA synthesis, this occurs on both the leading and lagging strands, not just the leading strand.

This problem has been solved

Similar Questions

Which is true during DNA replication?Group of answer choicesDNA ligase replaces the nucleotides in the RNA primer with DNA on the newly synthesised strands.RNA primers bound to both the leading and lagging strand are degraded by 5' - 3' exonucleases.DNA polymerase III synthesises the leading strand and DNA polymerase I synthesises the lagging strandPrimase is required to make primers on the lagging strand only

Which statement about DNA replication is FALSE?View Available Hint(s)for Part EThe lagging strand is made of a series of pieces that must be joined together to make a continuous strand.DNA polymerase builds a new strand by adding DNA nucleotides one at a time.DNA ligase adds nucleotides to the lagging strand.Because the two strands of parental DNA run in opposite directions, the new strands must be made in different ways.The two strands of parental DNA are separated during DNA replication.

Which statement about DNA replication is CORRECT?View Available Hint(s)for Part BDNA ligase helps assemble the leading strand.The leading strand is built continuously, and the lagging strand is built in pieces.The leading strand is one of the strands of parental DNA.The lagging strand is one of the strands of parental DNA.The lagging strand is built continuously.

For normal replication of DNA in eukaryotes, which one of the following statements is most correct?Group of answer choicesA single strand copy of the leading strand is made first, and then a complementary strand is synthesised to form a new double helix. This is performed entirely by the enzyme DNA polymerase.In making two copies, each strand of the original DNA is used as a template (semiconservative replication). This is performed by DNA polymerase with assistance from several additional enzymes.In making two copies, each strand of the original DNA is used as a template (semiconservative replication). This is performed entirely by the enzyme DNA polymerase.A single strand copy of the leading strand is made first, and then a complementary strand is synthesised to form a new double helix. This is performed by DNA polymerase with assistance from several additional enzymes.

Which is true during DNA replication?Group of answer choicesDNA ligase is the last step of the polymerisation reaction for the lagging strand, but is not used on the leading strand.DnaA binds to regions that are rich in AT as this purine-purine base pairing forms only two hydrogen bonds.The β sliding clamp prevents the dissociation of DNA polymerase III, increasing the length of DNA each polymerase can synthesise.DNA gyrase binds to and applies tension to the lagging strand.

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