Which is true during DNA replication?Group of answer choicesDNA ligase is the last step of the polymerisation reaction for the lagging strand, but is not used on the leading strand.DnaA binds to regions that are rich in AT as this purine-purine base pairing forms only two hydrogen bonds.The β sliding clamp prevents the dissociation of DNA polymerase III, increasing the length of DNA each polymerase can synthesise.DNA gyrase binds to and applies tension to the lagging strand.
Question
Which is true during DNA replication?Group of answer choicesDNA ligase is the last step of the polymerisation reaction for the lagging strand, but is not used on the leading strand.DnaA binds to regions that are rich in AT as this purine-purine base pairing forms only two hydrogen bonds.The β sliding clamp prevents the dissociation of DNA polymerase III, increasing the length of DNA each polymerase can synthesise.DNA gyrase binds to and applies tension to the lagging strand.
Solution
The correct statement during DNA replication is: "The β sliding clamp prevents the dissociation of DNA polymerase III, increasing the length of DNA each polymerase can synthesise."
Here's why:
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DNA ligase is used in both the leading and lagging strands. It seals the gaps between the Okazaki fragments on the lagging strand and any nicks present on the leading strand.
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DnaA does bind to regions rich in AT, but AT is not a purine-purine base pairing. Adenine (A) is a purine and Thymine (T) is a pyrimidine.
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The β sliding clamp does indeed prevent the dissociation of DNA polymerase III, allowing it to synthesize longer strands of DNA without falling off.
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DNA gyrase does not bind to and apply tension to the lagging strand. Instead, it relieves the tension in the double helix ahead of the replication fork by introducing negative supercoils.
Similar Questions
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