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Which statement is correct regarding CDK?Group of answer choicesPhosphorylation of Tyr-15 activates CDK.It contains a destruction box which allows it to be ubiquitinated by the DBRP.It is an enzyme that removes phosphate groups from other proteins.Phosphatases are required for the activation of CDK.

Question

Which statement is correct regarding CDK?Group of answer choicesPhosphorylation of Tyr-15 activates CDK.It contains a destruction box which allows it to be ubiquitinated by the DBRP.It is an enzyme that removes phosphate groups from other proteins.Phosphatases are required for the activation of CDK.

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Solution

The correct statement regarding CDK (Cyclin-Dependent Kinases) is "Phosphatases are required for the activation of CDK."

Here's why:

  1. Phosphorylation of Tyr-15 does not activate CDK. In fact, it inhibits CDK activity. Activation of CDK requires dephosphorylation at this site.

  2. CDK does not contain a destruction box. The destruction box is a sequence found in cyclins, not in CDKs. The destruction box allows cyclins to be ubiquitinated and targeted for proteasomal degradation.

  3. CDK is not an enzyme that removes phosphate groups from other proteins. It is a kinase, which means it adds phosphate groups to other proteins. The removal of phosphate groups is carried out by phosphatases.

  4. Phosphatases are indeed required for the activation of CDK.

This problem has been solved

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