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Which repair pathway would be used to repair a cytosine that has been turned into a uracil Group of answer choices nucleotide excision repair Base excision repair None of them. Uracil is a normal base so this is not a problem Mismatch repair

Question

Which repair pathway would be used to repair a cytosine that has been turned into a uracil Group of answer choices

nucleotide excision repair

Base excision repair

None of them. Uracil is a normal base so this is not a problem

Mismatch repair

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Solution

The repair pathway that would be used to repair a cytosine that has been turned into a uracil is Base excision repair.

Here's a step-by-step explanation:

  1. In DNA, cytosine is one of the four nucleotide bases and uracil is not. Uracil is normally found in RNA. If a cytosine in DNA is mistakenly altered into a uracil, it's considered a DNA damage.

  2. The Base Excision Repair (BER) pathway is specifically designed to correct small, non-helix-distorting base lesions from the genome. The process is initiated by DNA glycosylases, which recognize and remove specific altered bases, creating an apurinic/apyrimidinic site (AP site).

  3. The AP site is then recognized by an AP endonuclease that cleaves the phosphodiester bond.

  4. The resulting single-strand break can then be processed by either short-patch (where a single nucleotide is replaced) or long-patch BER (where 2-10 new nucleotides are synthesized).

  5. In this case, the uracil would be recognized and removed by a specific DNA glycosylase (UNG - uracil-DNA glycosylase), and the resulting AP site would be processed by the BER pathway, effectively replacing the uracil with a cytosine.

So, the correct answer is Base excision repair.

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Similar Questions

Which accurately describes the Base excision repair pathway of DNA repair?Group of answer choicesIt starts with DNA glycosylase cutting the DNA backbone. It can repair the DNA without cutting the phosphate backboneIt is the main pathway for repairing large lesions like thymine dimers.It can be used to repair missing bases or damaged bases.

Which is true about base excision repair:Group of answer choicesIt can repair pyrimidine dimers.DNA polymerase I replaces the short row of nucleotides using its 3’ to 5’ exonuclease activity.In E. coli, it repairs a mismatch in a newly synthesised DNA strand.DNA ligase is required to repair the nick formed by DNA polymerase I

Which of the four DNA repair systems described in this subject is specific to E coli?Group of answer choicesBase excision repairNucleotide excision repairDirect repairMismatch repair

In nucleotide-excision repair, the first enzyme to act is: Group of answer choices excinuclease DNA ligase DNA polymerase I DNA helicase

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