Which is true about base excision repair:Group of answer choicesIt can repair pyrimidine dimers.DNA polymerase I replaces the short row of nucleotides using its 3’ to 5’ exonuclease activity.In E. coli, it repairs a mismatch in a newly synthesised DNA strand.DNA ligase is required to repair the nick formed by DNA polymerase I
Question
Which is true about base excision repair:Group of answer choicesIt can repair pyrimidine dimers.DNA polymerase I replaces the short row of nucleotides using its 3’ to 5’ exonuclease activity.In E. coli, it repairs a mismatch in a newly synthesised DNA strand.DNA ligase is required to repair the nick formed by DNA polymerase I
Solution
The correct statement about base excision repair is: "DNA ligase is required to repair the nick formed by DNA polymerase I."
Here's why:
- Base excision repair does not repair pyrimidine dimers. This is typically done by nucleotide excision repair.
- DNA polymerase I does not replace the short row of nucleotides using its 3’ to 5’ exonuclease activity in base excision repair. This activity is used for proofreading during DNA replication.
- In E. coli, mismatch repair, not base excision repair, is used to repair a mismatch in a newly synthesized DNA strand.
- DNA ligase is indeed required in base excision repair to seal the nick (gap) left by DNA polymerase I after it has replaced the damaged nucleotide. This is the correct statement.
Similar Questions
Which accurately describes the Base excision repair pathway of DNA repair?Group of answer choicesIt starts with DNA glycosylase cutting the DNA backbone. It can repair the DNA without cutting the phosphate backboneIt is the main pathway for repairing large lesions like thymine dimers.It can be used to repair missing bases or damaged bases.
In nucleotide-excision repair, the first enzyme to act is: Group of answer choices excinuclease DNA ligase DNA polymerase I DNA helicase
Which repair pathway would be used to repair a cytosine that has been turned into a uracil Group of answer choices nucleotide excision repair Base excision repair None of them. Uracil is a normal base so this is not a problem Mismatch repair
Which of the four DNA repair systems described in this subject is specific to E coli?Group of answer choicesBase excision repairNucleotide excision repairDirect repairMismatch repair
In base excision repair, which enzyme(s) cleave(s) the glycosidic bond of the altered nucleotide?Group of answer choicesDNA glycosylaseAP endonucleaseDNA polymeraseDNA ligaseall of the above
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