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A 40-year old male presented with chronic hypertension, headaches, palpitations and excessive diaphoresis. Urine and plasma metanephrines were elevated. What is your primary impression?

Question

A 40-year old male presented with chronic hypertension, headaches, palpitations and excessive diaphoresis. Urine and plasma metanephrines were elevated. What is your primary impression?

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Solution

Based on the symptoms presented and the elevated levels of metanephrines in the urine and plasma, the primary impression would be Pheochromocytoma. Pheochromocytoma is a rare, usually benign, tumor that develops in cells in the center of an adrenal gland. This condition can cause persistent or episodic high blood pressure, which can be life-threatening. The symptoms described, such as chronic hypertension, headaches, palpitations, and excessive diaphoresis, are common in individuals with Pheochromocytoma. However, further diagnostic tests, such as imaging studies, are needed to confirm the diagnosis.

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