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Primary amines are identified by __________ reaction

Question

Primary amines are identified by __________ reaction

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Solution

Primary amines are identified by the Isocyanide or Carbylamine reaction. Here are the steps:

  1. The primary amine (RNH2) is heated with chloroform (CHCl3) and an alcoholic solution of potassium hydroxide (KOH).

  2. During this reaction, an unpleasant-smelling compound known as an isocyanide or carbylamine is formed. This isocyanide is identifiable by its strong, foul odor.

  3. The reaction is as follows: RNH2 + CHCl3 + 3KOH → RNC + 3KCl + 3H2O. The RNC is the isocyanide.

This reaction is not given by secondary and tertiary amines, so it is a good test for the presence of a primary amine.

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