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An electrophoretic separation of lactate dehydrogenase isoenzyme that demonstrates elevation in LD-1 greater than LD-2 could be indicative of:

Question

An electrophoretic separation of lactate dehydrogenase isoenzyme that demonstrates elevation in LD-1 greater than LD-2 could be indicative of:

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Solution

An elevation in LD-1 greater than LD-2 in an electrophoretic separation of lactate dehydrogenase isoenzyme could be indicative of a myocardial infarction, also known as a heart attack.

Here's a step-by-step explanation:

  1. Lactate dehydrogenase (LDH) is an enzyme found in almost all body tissues, but only released into the bloodstream when there's tissue damage.

  2. LDH is made up of five isoenzymes, which can be separated by electrophoresis. These isoenzymes are LD-1, LD-2, LD-3, LD-4, and LD-5.

  3. Under normal conditions, the LD-1 level is lower than the LD-2 level in the blood.

  4. However, when a heart attack occurs, heart cells are damaged and release their LDH. The LDH from heart cells is primarily LD-1.

  5. Therefore, after a heart attack, the LD-1 level in the blood can become higher than the LD-2 level. This is known as a "flipped LDH pattern" and is a strong indicator of a recent heart attack.

  6. So, an electrophoretic separation of lactate dehydrogenase isoenzyme that shows an elevation in LD-1 greater than LD-2 could be indicative of a myocardial infarction.

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