Which of the following statements is true about sulfa drugs?SELECT ALL THAT APPLYThey chemically resemble PABA, the natural substrate of a bacterial enzyme in the pathway used to produce folic acid.Sulfonamides were among the first synthetic antimicrobials used to combat bacterial infections.They act as competitive inhibitors of DNA gyrase.They are bacteriocidal.They have a narrow spectrum of action.They can only be administered orally.

How does the antibiotic sulfanilamide inhibit bacterial growth?ANSWERSulfanilamide is a competitive inhibitor that competes with para-aminobenzoic acid, thus affecting folic acid synthesis of a bacterial cell.Sulfanilamide is an antifungal agent and does not affect bacterial cells.Sulfanilamide is an allosteric inhibitor of the enzymes involved in folic acid synthesis, thus decreasing its amount in the bacterial cell, which will ultimately lead to the death of the cells.Sulfanilamide is a noncompetitive inhibitor that alters the shape of the enzyme responsible for folic acid synthesis in bacteria.

Antibiotics are _________________.ANSWERwholly manufactured by chemical processesnaturally occurring antibiotics chemically modified to improve their pharmacological actions and/or stabilitynaturally occurring antimicrobial compoundsa superfamily of drugs that work by blocking cell wall construction

Which of the following are not examples of intrinsic resistance of a bacterium to an antimicrobial drug?SELECT ALL THAT APPLYStaphylococcus aureus (VRSA) strains with altered cell wall–building enzymesMycoplasma pneumoniae lacking a cell wallMycobacterium tuberculosis altering its RNA polymerases to avoid binding by rifampinResistance in Gram-negative bacteria due to their outer membraneClostridioides difficile form endosporesMycobacterium tuberculosis have a waxy cell wall

Which statement is true about drug-drug interactions?Group of answer choicesThe concentration of the object drug increases when the precipitant drug is an inhibitorThe concentration of the object drug increases when the precipitant drug is an inducerThe pharmacodynamic effects of the object drug cannot be altered by a drug-drug interactionAll of the aboveNone of the above

Time left 0:13:22Question 10Not yet answeredMarked out of 1.00Flag questionQuestion text different metabolites, one of them is having anti-inflammatory effect:Question 10Answera.5 – aminosalicylateb.3 – sulfonamidec.Sulfapyridined.5 – sulfasalazine