How does the antibiotic sulfanilamide inhibit bacterial growth?ANSWERSulfanilamide is a competitive inhibitor that competes with para-aminobenzoic acid, thus affecting folic acid synthesis of a bacterial cell.Sulfanilamide is an antifungal agent and does not affect bacterial cells.Sulfanilamide is an allosteric inhibitor of the enzymes involved in folic acid synthesis, thus decreasing its amount in the bacterial cell, which will ultimately lead to the death of the cells.Sulfanilamide is a noncompetitive inhibitor that alters the shape of the enzyme responsible for folic acid synthesis in bacteria.
Question
How does the antibiotic sulfanilamide inhibit bacterial growth?ANSWERSulfanilamide is a competitive inhibitor that competes with para-aminobenzoic acid, thus affecting folic acid synthesis of a bacterial cell.Sulfanilamide is an antifungal agent and does not affect bacterial cells.Sulfanilamide is an allosteric inhibitor of the enzymes involved in folic acid synthesis, thus decreasing its amount in the bacterial cell, which will ultimately lead to the death of the cells.Sulfanilamide is a noncompetitive inhibitor that alters the shape of the enzyme responsible for folic acid synthesis in bacteria.
Solution
Sulfanilamide is a competitive inhibitor that competes with para-aminobenzoic acid (PABA) for the active site of the enzyme dihydropteroate synthase. This enzyme is involved in the synthesis of folic acid in bacteria.
Here are the steps:
- Sulfanilamide, due to its similar structure to PABA, binds to the active site of the enzyme dihydropteroate synthase.
- This prevents PABA from binding to the enzyme and participating in the synthesis of folic acid.
- Folic acid is crucial for bacteria to synthesize nucleic acids (DNA and RNA) and proteins. Without it, these processes are hindered.
- The lack of nucleic acids and proteins inhibits the growth and multiplication of bacteria, eventually leading to their death.
Therefore, by inhibiting the synthesis of folic acid, sulfanilamide effectively inhibits bacterial growth.
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