The statement that best captures the aetiology of the acute response phase of extrinsic (atopic) asthma is: "Chemical mediators are released from presensitized mast cells."

Here's why:

1. "IgG production is heightened as a consequence of exposure to an allergen." - This statement is incorrect because in atopic asthma, it's actually IgE, not IgG, that is produced in response to allergen exposure.

2. "Chemical mediators are released from presensitized mast cells." - This statement is correct. In the acute phase of atopic asthma, exposure to an allergen triggers the release of chemical mediators like histamine from mast cells that have been previously sensitized by IgE. This leads to bronchoconstriction, increased mucus production, and inflammation.

3. "Airway remodeling results in airflow limitations." - This statement describes a feature of chronic asthma, not the acute response phase.

4. "Epithelial injury and oedema occur along with changes in mucociliary function." - While these changes can occur in asthma, they are not the primary cause of the acute response phase.

Question

The statement that best captures the aetiology of the acute response phase of extrinsic (atopic) asthma is: "Chemical mediators are released from presensitized mast cells."

Here's why:

1. "IgG production is heightened as a consequence of exposure to an allergen." - This statement is incorrect because in atopic asthma, it's actually IgE, not IgG, that is produced in response to allergen exposure.

2. "Chemical mediators are released from presensitized mast cells." - This statement is correct. In the acute phase of atopic asthma, exposure to an allergen triggers the release of chemical mediators like histamine from mast cells that have been previously sensitized by IgE. This leads to bronchoconstriction, increased mucus production, and inflammation.

3. "Airway remodeling results in airflow limitations." - This statement describes a feature of chronic asthma, not the acute response phase.

4. "Epithelial injury and oedema occur along with changes in mucociliary function." - While these changes can occur in asthma, they are not the primary cause of the acute response phase.

Knowee AI · Accepted Answer

The statement that best captures the aetiology of the acute response phase of extrinsic (atopic) asthma is: "Chemical mediators are released from presensitized mast cells."

Here's why:

1. "IgG production is heightened as a consequence of exposure to an allergen." - This statement is incorrect because in atopic asthma, it's actually IgE, not IgG, that is produced in response to allergen exposure.

2. "Chemical mediators are released from presensitized mast cells." - This statement is correct. In the acute phase of atopic asthma, exposure to an allergen triggers the release of chemical mediators like histamine from mast cells that have been previously sensitized by IgE. This leads to bronchoconstriction, increased mucus production, and inflammation.

3. "Airway remodeling results in airflow limitations." - This statement describes a feature of chronic asthma, not the acute response phase.

4. "Epithelial injury and oedema occur along with changes in mucociliary function." - While these changes can occur in asthma, they are not the primary cause of the acute response phase.

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