A 68-year-old man comes to the physician for a follow-up examination. He has type 2 diabetes mellitus, hypertension, and chronic kidney disease. Medications include insulin, metoprolol, and atorvastatin. Physical examination shows pitting edema of both ankles. Serum creatinine concentration is 4.5 mg/dL. Which of the following sets of serum findings is most likely in this patient?Parathyroid hormone (PTH) Vitamin D Calcium PhosphorusA Decreased increased increased increasedB Increased decreased decreased increasedC Increased decreased increased decreasedD Increased decreased decreased decreasedE Decreased decreased decreased increased
Question
A 68-year-old man comes to the physician for a follow-up examination. He has type 2 diabetes mellitus, hypertension, and chronic kidney disease. Medications include insulin, metoprolol, and atorvastatin. Physical examination shows pitting edema of both ankles. Serum creatinine concentration is 4.5 mg/dL. Which of the following sets of serum findings is most likely in this patient?Parathyroid hormone (PTH) Vitamin D Calcium PhosphorusA Decreased increased increased increasedB Increased decreased decreased increasedC Increased decreased increased decreasedD Increased decreased decreased decreasedE Decreased decreased decreased increased
Solution
This patient's chronic kidney disease (CKD) is likely causing a condition known as secondary hyperparathyroidism. In CKD, the kidneys are less able to excrete phosphorus, leading to hyperphosphatemia. The kidneys also have a decreased ability to convert vitamin D to its active form, leading to vitamin D deficiency. Both hyperphosphatemia and vitamin D deficiency lead to hypocalcemia. The body responds to hypocalcemia by increasing parathyroid hormone (PTH) secretion, hence secondary hyperparathyroidism. Therefore, the most likely set of serum findings in this patient would be increased PTH, decreased vitamin D, decreased calcium, and increased phosphorus (Option B).
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