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The use of two antimicrobial agents to treat an infectious disease sometimes produces a degree of pathogen killing that is far greater than that achieved by either drug alone. This is known as synergism. Many urinary, respiratory, and gastrointestinal infections respond particularly well to a combination of trimethoprim and sulfamethoxazole, a combination referred to as co-trimoxazole; brand names include Bactrim and Septra. There are situations, however, when two drugs are prescribed (perhaps by two different clinicians who are treating the patient’s infection) that actually work against each other. This is known as antagonism. The extent of pathogen killing is less than that achieved by either drug alone. (1 Point)TrueFalse

Question

The use of two antimicrobial agents to treat an infectious disease sometimes produces a degree of pathogen killing that is far greater than that achieved by either drug alone. This is known as synergism. Many urinary, respiratory, and gastrointestinal infections respond particularly well to a combination of trimethoprim and sulfamethoxazole, a combination referred to as co-trimoxazole; brand names include Bactrim and Septra. There are situations, however, when two drugs are prescribed (perhaps by two different clinicians who are treating the patient’s infection) that actually work against each other. This is known as antagonism. The extent of pathogen killing is less than that achieved by either drug alone. (1 Point)TrueFalse

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Solution

True

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In some cases, a single antimicrobial agent is not sufficient to destroy all the pathogens that develop during the course of a disease; thus, two or more drugs may be used simultaneously to kill all the pathogens and to prevent resistant mutant pathogens from emerging. In tuberculosis, for example, in which multidrug-resistant strains of Mycobacterium tuberculosis are frequently encountered, four drugs (isoniazid, rifampin, pyrazinamide, and ethambutol) are routinely prescribed, and as many as 10 drugs may be required for especially resistant strains.(1 Point)TrueFalse

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