A recessively inherited human blood disorder in which a single nucleotide change in the α-globin gene causes hemoglobin to aggregate, changing red blood cell shape and causing multiple symptoms.Group of answer choicesTay-Sachs diseaseHuntington’s diseasesickle-cell diseasecystic fibrosis

Which is a genetic disorder in which abnormal hemoglobin leads to fragile red blood cells and obstructed blood vessels? (1) phenylketonuria (2) sickle-cell anemia (3) leukemia (4) Down syndrome

A human genetic disease caused by a sex-linked recessive allele resulting in the absence of one or more blood-clotting proteins, and characterized by excessive bleeding following injury.Group of answer choicessickle-cell diseasehemophiliaDown syndromeTay-Sachs diseaseDuchenne muscular dystrophyHuntington’s diseaseNext

A human genetic disease caused by a dominant allele; characterized by uncontrollable body movements and degeneration of the nervous system; usually fatal 10 to 20 years after the onset of symptoms.Group of answer choicesTay-Sachs diseaseHuntington’s diseasesickle-cell diseasecystic fibrosis

Consider the genetic condition known as "Sickle Cell Disease."Healthy Red Blood Cells (left) and Red Blood Cells in an Individual with Sickle Cell Anemia (right) by Jack Potte (CC0)Most people have oval-shaped red blood cells. At some point in time, a mutation happened within the human genetic code, causing some people to have crescent-shaped blood cells (sickle cells).In terms of genotypes, someone who is homozygous dominant (AA) has oval-shaped red blood cells, and someone who is homozygous recessive (SS) has crescent-shaped blood cells. Someone who is heterozygous (AS) has a mixture of oval- and crescent-shaped blood cells.How did the mutation in the genetic code directly lead to a change blood cell shape?Elimination ToolSelect one answerAThe change in DNA changed the cell's instructions for making certain carbohydrates, which impacted blood cell shape.BThe change in DNA changed the cell's instructions for making certain proteins, which impacted blood cell shape.CThe change in DNA changed the cell's instructions for making certain lipids, which impacted blood cell shape.DThe change in DNA changed the cell's instructions for making certain carbohydrates, lipids, and proteins- all of which together impacted blood cell shape.Skip For Now

Which of the following describes sickle-cell disease? Multiple select question.Red blood cells take on a translucent appearance.It is a hereditary condition.The heme part of hemoglobin is abnormal.Red blood cells are misshapen.It can be caused by iron deficiency.