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Which of the following describes sickle-cell disease? Multiple select question.Red blood cells take on a translucent appearance.It is a hereditary condition.The heme part of hemoglobin is abnormal.Red blood cells are misshapen.It can be caused by iron deficiency.

Question

Which of the following describes sickle-cell disease? Multiple select question.Red blood cells take on a translucent appearance.It is a hereditary condition.The heme part of hemoglobin is abnormal.Red blood cells are misshapen.It can be caused by iron deficiency.

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Solution

Sickle-cell disease is described by the following:

  • It is a hereditary condition: This is true. Sickle cell disease is an inherited genetic condition, which means it is passed down from parents to their children through genes.

  • Red blood cells are misshapen: This is also true. In sickle cell disease, the red blood cells become rigid and sticky, and are shaped like sickles or crescent moons.

The other options are not accurate descriptions of sickle-cell disease:

  • Red blood cells take on a translucent appearance: This is not a characteristic of sickle cell disease.

  • The heme part of hemoglobin is abnormal: In sickle cell disease, it's not the heme part of the hemoglobin that's abnormal, but the beta globin gene.

  • It can be caused by iron deficiency: This is not true. Sickle cell disease is not caused by iron deficiency. It's a genetic disorder that you inherit from your parents.

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Sickle cell anemia is caused by a allele because this mutation has more than one effect on the phenotype.

Consider the genetic condition known as "Sickle Cell Disease."Healthy Red Blood Cells (left) and Red Blood Cells in an Individual with Sickle Cell Anemia (right) by Jack Potte (CC0)Most people have oval-shaped red blood cells. At some point in time, a mutation happened within the human genetic code, causing some people to have crescent-shaped blood cells (sickle cells).In terms of genotypes, someone who is homozygous dominant (AA) has oval-shaped red blood cells, and someone who is homozygous recessive (SS) has crescent-shaped blood cells. Someone who is heterozygous (AS) has a mixture of oval- and crescent-shaped blood cells.How did the mutation in the genetic code directly lead to a change blood cell shape?Elimination ToolSelect one answerAThe change in DNA changed the cell's instructions for making certain carbohydrates, which impacted blood cell shape.BThe change in DNA changed the cell's instructions for making certain proteins, which impacted blood cell shape.CThe change in DNA changed the cell's instructions for making certain lipids, which impacted blood cell shape.DThe change in DNA changed the cell's instructions for making certain carbohydrates, lipids, and proteins- all of which together impacted blood cell shape.Skip For Now

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