A patient is taking a daily 25 mg prednisolone tablet which is 100%bioavailable for treatment of ulcerative colitis, and his condition iswell controlled. The patient is to start taking a new prednisoloneformulation which is known to have bioavailability of 80%. What willbe the required dos from this formulation to control the patient’scondition

The elimination rate constant of ibuprofen is 0.1155/hr and its volumeof distribution is 0.17 L/kg. What will be the dosing regimen requiredfor a 70-kg man to achieve an average plasma concentration of 50mg/L at steady state (bioavailability is 100%)

Dosage and Concentration:

Consider the following scenarioYour local community pharmacy has received the following prescription which needs to be extemporaneously prepared. The medication is prescribed for Master Ben Bee, 10 year old, of average body weight who has been diagnosed with acute uncomplicated diarrhoea.RxKaolin Mixt. Paediatric BPLight Kaolin                                          1gRaspberry Syrup                                  1mLBenzoic Acid Solution                           0.1mLDouble-strength Chloroform Water        2.5 mLPurified Water to                                  5 mLM 100 mLGive 5-10 ml qqh prnAnswer the following questions:List the function of all the ingredients contained in the formulation. Explain why there are more than one preservative present in this formulation.Discuss the formulation factors that can influence the stability of this product.In your compounding dispensary, there is a stock solution of concentrated chloroform water (CCW) on the shelf. Calculate how much CCW solution (in mL) you will need use to prepare this product.Calculate all the quantities of the excipients you will need to dispense this prescription.Apart from the product the doctor has prescribed, can you suggest another pharmacy product (oral dosage form) that can be recommended to manage an acute uncomplicated diarrhoea in childrenThe following information may be helpful when answering these questions:Kaolin - is hydrated aluminium silicate powder  with the particle diameter of 0.6-0.8 µm. It is practically insoluble in water, organic solvents, dilute acid and solutions of alkali hydroxides. pH is 4.0 - 7.5 for a 20% w/v aqueous slurry. It is used in oral and topical pharmaceutical formulations as adsorbent. Oral doses of up to about 24 g of kaolin have been administered in the treatment of diarrhea. The adsorbent properties of kaolin may interfere with the absorption of other orally administered drugs. Light kaolin contains suitable dispersing agent. Kaolin may contain Clostridium and bacillus spores. Mixtures containing kaolin should be freshly prepared unless kaolin has been sterilised.Benzoic acid - is widely used in cosmetics, foods, and pharmaceuticals as an antimicrobial preservative. Benzoic acid solutions contain 1 - 5% benzoic acid. Greatest antimicrobial activity is seen at pH values between 2.5 - 4.5. A 0.1% w/v aqueous solution of benzoic acid has been reported as being stable for at least 8 weeks when stored at room temperature. Benzoic acid may dissociate into benzoate anion (-) which can adsorb onto drug particles in suspensions to affect the physical stability of the product.Concentrated chloroform water and chloroform water contain 10% v/v and 0.25% v/v of chloroform in water respectively.Ref: APF, Martindale, BP, Pharmaceutical excipients

What dosage form meets the following description? A liquid preparation that contains immiscible or undissolved API distributed throughout a carrier. A. transdermal B. solution C. suppository D. disperse system

Make 200 mL of the following formula:Allopurinol  200 mgSyrup 1 mLMucilage of Tragacanth 15%Concentrated Chloroform Water 2.5%Purified water to 10 mLUse Allopurinol tablets 100mg. How many tablets are required ?