Scenario 5 Martin, a 25-year-old male, has recently been diagnosed with a mitochondrial disease and is seeking information. You know that mitochondrial disease is a genetic disease caused by a mutation in one of the 22 autosomal chromosomes leading to a reduced function of the mitochondria. Question 11. Martin asks if his exhaustion is associated with his disease – knowing the function of the mitochondria, what would you say to Martin (in lay terms)? (2 marks) Question 12. Martin is concerned about his future children inheriting the disease. Answer the following questions regarding inheritance patterns (you might like to use punnet squares to help you prepare your response, but they don’t need to be included in your answer). (6 marks) a) If both parents are carriers (heterozygous) for a recessively inherited gene, what percentage of offspring will manifest the disease? b) If only one parent contains a single copy (heterozygous) of a dominantly inherited disorder and the other parent is homozygous recessive, what percentage of offspring will have the disorder? c) A mother is a carrier for an X-linked disease, what percentage of males will manifest the disease? And what percentage of females will manifest the disease? d) Explain why there is a difference in X-linked inheritance patterns.
Question
Scenario 5 Martin, a 25-year-old male, has recently been diagnosed with a mitochondrial disease and is seeking information. You know that mitochondrial disease is a genetic disease caused by a mutation in one of the 22 autosomal chromosomes leading to a reduced function of the mitochondria. Question 11. Martin asks if his exhaustion is associated with his disease – knowing the function of the mitochondria, what would you say to Martin (in lay terms)? (2 marks) Question 12. Martin is concerned about his future children inheriting the disease. Answer the following questions regarding inheritance patterns (you might like to use punnet squares to help you prepare your response, but they don’t need to be included in your answer). (6 marks) a) If both parents are carriers (heterozygous) for a recessively inherited gene, what percentage of offspring will manifest the disease? b) If only one parent contains a single copy (heterozygous) of a dominantly inherited disorder and the other parent is homozygous recessive, what percentage of offspring will have the disorder? c) A mother is a carrier for an X-linked disease, what percentage of males will manifest the disease? And what percentage of females will manifest the disease? d) Explain why there is a difference in X-linked inheritance patterns.
Solution
Question 11: Yes, Martin, your exhaustion is indeed associated with your disease. Mitochondria are often referred to as the "powerhouses" of the cell because they generate most of the cell's supply of energy. If the mitochondria are not functioning properly, as in your case, the cells may not get the energy they need, which can lead to fatigue or exhaustion.
Question 12: a) If both parents are carriers for a recessively inherited gene, there is a 25% chance that an offspring will manifest the disease. This is because the child would need to inherit the defective gene from both parents to show symptoms of the disease.
b) If one parent is heterozygous for a dominantly inherited disorder and the other parent is homozygous recessive, there is a 50% chance that an offspring will have the disorder. This is because the child only needs to inherit one copy of the defective gene to show symptoms of the disease.
c) If a mother is a carrier for an X-linked disease, 50% of her male offspring will manifest the disease, while none of her female offspring will manifest the disease. However, 50% of her female offspring will be carriers of the disease.
d) There is a difference in X-linked inheritance patterns because males have only one X chromosome, while females have two. This means that males are more likely to manifest X-linked diseases, as they only need to inherit one copy of the defective gene. Females, on the other hand, would need to inherit two copies of the defective gene to show symptoms of the disease. However, if a female inherits one copy of the defective gene, she will be a carrier and can pass the gene on to her offspring.
Similar Questions
Martin is concerned about his future children inheriting the disease. Answer the following questions regarding inheritance patterns (you might like to use punnet squares to help you prepare your response, but they don’t need to be included in your answer). A mother is a carrier for an X-linked disease, what percentage of males will manifest the disease? And what percentage of females will manifest the disease? answer: The male offspring of the mother will have 50% of manifesting the disease, and there will be none for the female offspring. However, the female offspring will be the carriers of the disease with 50%. is the statement correct?
A pedigree diagram of a disorder caused by a mitochondrial DNA mutation will show:Group of answer choicesmales and females affected equally, affected children have at least one affected parent, and that heterozygotes are affected.more males than females are affected, affected sons can have parents with normal phenotypes, affected female offspring have an affected father, and the mother must be affected or be a carrier.all of the offspring of an affected female are affected.males and females affected equally, affected children can have unaffected parents, and that heterozygotes have a normal phenotype.males and females affected equally, heterozygotes have a normal phenotype, and affected children can have unaffected parents.
A pedigree diagram shows males and females affected equally, heterozygotes have a normal phenotype, and affected children can have unaffected parents.Group of answer choicesautosomal recessive disordersex-linked disorderautosomal dominant disordermitochondrial disorder
A pedigree diagram showing an inheritance pattern in which all of the offspring of an affected female are affected.Group of answer choicessex-linked recessiveautosomal dominantautosomal recessivemitochondrial DNA mutationsex-linked dominantNext
If a pedigree diagram shows that all of the offspring of an affected female are affected, then the disorder is likely _____.Group of answer choicesX-linked recessivemitochondrial DNA mutationautosomal dominantautosomal recessive
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