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A 48-year-old man presents to the hospital with swelling of the abdomen and legs. He first noticed shortness of breath with exertion several months ago, and has had a few episodes where he momentarily became lightheaded and lost consciousness. Now the symptoms have been progressing with increased dyspnea and edema. He reports that he has always lived a healthy lifestyle and has no past medical history. There is no family history of any cardiac or pulmonary disease, or any cancer. He was born in Brazil and moved to the United States at the age of 43. He does not smoke or drink alcohol. On cardiac examination, the apex is displaced laterally with an S3 on auscultation. Estimated central venous pressure is 15 mmHg, and there are faint crackles at the base of his lungs. He has hepatomegaly with shifting dullness and bilateral pitting edema of the lower extremities. An ECG is normal, with no visible Q waves. Which infectious etiology is most likely responsible for this patient's disease?

Question

A 48-year-old man presents to the hospital with swelling of the abdomen and legs. He first noticed shortness of breath with exertion several months ago, and has had a few episodes where he momentarily became lightheaded and lost consciousness. Now the symptoms have been progressing with increased dyspnea and edema. He reports that he has always lived a healthy lifestyle and has no past medical history. There is no family history of any cardiac or pulmonary disease, or any cancer. He was born in Brazil and moved to the United States at the age of 43. He does not smoke or drink alcohol. On cardiac examination, the apex is displaced laterally with an S3 on auscultation. Estimated central venous pressure is 15 mmHg, and there are faint crackles at the base of his lungs. He has hepatomegaly with shifting dullness and bilateral pitting edema of the lower extremities. An ECG is normal, with no visible Q waves. Which infectious etiology is most likely responsible for this patient's disease?

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Solution

This patient's symptoms of heart failure (e.g., dyspnea, edema, elevated jugular venous pressure, displaced apical impulse) and physical examination findings suggestive of a dilated cardiomyopathy (e.g., S3, laterally displaced apical impulse) are most likely due to Chagas disease (caused by Trypanosoma cruzi). Chagas disease is endemic in Central and South America, including Brazil, where this patient was born and lived most of his life. The disease is transmitted by the reduviid bug, which infests poorly constructed homes in rural areas. After an acute phase characterized by nonspecific symptoms (e.g., fever, malaise), the disease enters a chronic phase that can last for decades. During the chronic phase, T. cruzi parasites infiltrate various tissues, including the myocardium, leading to cell death and inflammation. Over time, this can result in a dilated cardiomyopathy characterized by heart failure, arrhythmias, and thromboembolism. The diagnosis of Chagas disease can be confirmed by serologic testing.

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