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A 57-year-old woman is brought into the emergency department because of the sudden onset of severe left-sided chest pain and shortness of breath. She had flown back to the United States yesterday following a tour of Southeast Asia. Other than feeling tired after her long trip, she was in her usual state of good health, but this afternoon she had the sudden onset of stabbing left chest pain and noted severe shortness of breath. She denies any previous history of peripheral vascular, cardiac, or respiratory disease. Past medical history is unremarkable, and she is not currently taking any medications. On examination, the patient is in severe discomfort. Temperature is 100.5°F (38°C) orally, pulse 130, respirations 26, and BP 130/90. Pulse oximetry reveals an O2 saturation of 88% while the patient is breathing room air. Physical examination is otherwise unremarkable. Stat labs show normal kidney function. A chest radiograph and ECG are obtained.  What is the most appropriate action at this time?

Question

A 57-year-old woman is brought into the emergency department because of the sudden onset of severe left-sided chest pain and shortness of breath. She had flown back to the United States yesterday following a tour of Southeast Asia. Other than feeling tired after her long trip, she was in her usual state of good health, but this afternoon she had the sudden onset of stabbing left chest pain and noted severe shortness of breath. She denies any previous history of peripheral vascular, cardiac, or respiratory disease. Past medical history is unremarkable, and she is not currently taking any medications. On examination, the patient is in severe discomfort. Temperature is 100.5°F (38°C) orally, pulse 130, respirations 26, and BP 130/90. Pulse oximetry reveals an O2 saturation of 88% while the patient is breathing room air. Physical examination is otherwise unremarkable. Stat labs show normal kidney function. A chest radiograph and ECG are obtained.  What is the most appropriate action at this time?

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Solution

The patient's symptoms and recent history of long-distance travel suggest a high probability of pulmonary embolism (PE). The most appropriate action at this time would be to initiate anticoagulation therapy to prevent further clot formation and to arrange for a confirmatory test such as a CT pulmonary angiogram. This should be done as soon as possible, as PE can be life-threatening. It's also important to provide supplemental oxygen to address the patient's hypoxia.

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