MHC class I is BEST DESCRIBED by which statement?Select one alternative:It presents viral peptides to CD8 T cells.It presents foreign peptides to CD4 T cells.It captures foreign peptides from extracellular pathogens.It is only expressed on specialised antigen presenting cells.
Question
MHC class I is BEST DESCRIBED by which statement?Select one alternative:It presents viral peptides to CD8 T cells.It presents foreign peptides to CD4 T cells.It captures foreign peptides from extracellular pathogens.It is only expressed on specialised antigen presenting cells.
Solution
The best description for MHC class I is that it presents viral peptides to CD8 T cells.
Here's why:
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MHC class I molecules are found on all nucleated cells in the body. They present endogenous antigens, which are typically derived from intracellular pathogens like viruses, to CD8+ cytotoxic T cells.
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MHC class II molecules, on the other hand, present exogenous antigens, which are typically derived from extracellular pathogens, to CD4+ helper T cells.
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While it's true that MHC molecules can present foreign peptides, the distinction between MHC class I and II is in the type of T cell they present to (CD8+ vs CD4+) and the source of the antigens they present (intracellular vs extracellular).
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MHC class I is not only expressed on specialised antigen presenting cells, but on all nucleated cells in the body. This is a key difference between MHC class I and II, as the latter is primarily expressed on specialised antigen presenting cells like dendritic cells, macrophages, and B cells.
So, the statement "MHC class I presents viral peptides to CD8 T cells" is the best description.
Similar Questions
Which statement is TRUE about the CD4 subset of T cells?Select one alternative:They recognise peptides presented by MHC class I.They recognise peptides presented by MHC class II.They kill cells that have phagocytosed bacteria.They kill virally infected cells.
Class I MHC molecule can ____________.bind to CD8 molecules on T cellspresent antigens to B cellsbind to CD4 molecules on T cellsbind to antibodies
The major histocompatibility complex type I (MHC I) __________.ANSWERinteracts with CD4 on T helper cellsis found only on antigen-presenting cellsis found on all body cells except red blood cellspresents extracellular antigens
Which of the following cell types does not express MHC class I?Group of answer choiceserythrocytehepatocytelymphocytedendritic cellneutrophil
Regarding the major histocompatibility class II (MHC II) molecule, which of the following statements is TRUE?Select one alternative:Antigenic peptides are anchored along the peptide binding groove in MHC II.Each MHC II molecule can present only one specific (cognate) antigen.MHC II molecules present endogenous antigens, from within the cell.MHC II is expressed on all nucleated cells in the body.
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