A 52-year-old female presents to the emergency room with swelling over her right calf for the past 3 days. Her right calf is warm, erythematous, and tender to palpation. A duplex is performed and shows a deep vein thrombosis (DVT). This is her first DVT. She is started on warfarin and told that she must continue it for the next 3 months. What effect does warfarin have on the coagulation panel?Question 6Answera.Increases bleeding timeb.Increases prothrombin timec.Decreases partial thromboplastin timed.Increases partial thromboplastin timee.Decreases prothrombin time
Question
A 52-year-old female presents to the emergency room with swelling over her right calf for the past 3 days. Her right calf is warm, erythematous, and tender to palpation. A duplex is performed and shows a deep vein thrombosis (DVT). This is her first DVT. She is started on warfarin and told that she must continue it for the next 3 months. What effect does warfarin have on the coagulation panel?Question 6Answera.Increases bleeding timeb.Increases prothrombin timec.Decreases partial thromboplastin timed.Increases partial thromboplastin timee.Decreases prothrombin time
Solution
Para responder a la pregunta sobre el efecto de la warfarina en el panel de coagulación, sigamos estos pasos:
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Entender el mecanismo de acción de la warfarina: La warfarina es un anticoagulante que actúa inhibiendo la síntesis de factores de coagulación dependientes de la vitamina K (factores II, VII, IX y X).
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Identificar los componentes del panel de coagulación:
- Tiempo de sangrado (bleeding time): Mide la función plaquetaria y no se ve afectado por la warfarina.
- Tiempo de protrombina (prothrombin time, PT): Mide la vía extrínseca de la coagulación, que incluye los factores dependientes de la vitamina K.
- Tiempo de tromboplastina parcial (partial thromboplastin time, PTT): Mide la vía intrínseca de la coagulación y no se ve directamente afectado por la warfarina.
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Determinar el efecto de la warfarina en cada componente:
- Bleeding time: No se ve afectado por la warfarina.
- Prothrombin time (PT): La warfarina prolonga el PT porque inhibe la síntesis de los factores de coagulación dependientes de la vitamina K.
- Partial thromboplastin time (PTT): Aunque la warfarina puede tener un efecto indirecto, no es el principal parámetro afectado.
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Conclusión: La warfarina aumenta el tiempo de protrombina (PT).
Por lo tanto, la respuesta correcta es:
b. Increases prothrombin time
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