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Julia’s flight has just landed from London. She is now experiencing excruciating pain is her right leg and notices that it is red and considerably swollen. She is told she has developed deep vein thrombosis on the long flight back to Australia. By reflecting on the BIOL122 learning material and your understanding of the Starling forces responsible for the distribution of water between the capillary and surrounding tissues, briefly describe how Julia’s deep vein thrombosis caused oedema in her right leg. (3 marks)

Question

Julia’s flight has just landed from London. She is now experiencing excruciating pain is her right leg and notices that it is red and considerably swollen. She is told she has developed deep vein thrombosis on the long flight back to Australia. By reflecting on the BIOL122 learning material and your understanding of the Starling forces responsible for the distribution of water between the capillary and surrounding tissues, briefly describe how Julia’s deep vein thrombosis caused oedema in her right leg. (3 marks)

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Solution

Deep vein thrombosis (DVT) is a condition where a blood clot forms in one of the deep veins of the body, often in the leg. This can lead to a blockage in the vein, causing blood to pool and pressure to build up, which can disrupt the balance of the Starling forces.

The Starling forces are responsible for the distribution of water between the capillary and surrounding tissues. They include hydrostatic pressure and oncotic pressure. Hydrostatic pressure, which is the blood pressure generated by the heart's contraction, tends to push fluid out of the capillaries into the tissues. Oncotic pressure, on the other hand, is the osmotic pressure exerted by proteins in the blood plasma, which tends to pull fluid back into the capillaries from the tissues.

In the case of DVT, the blood clot can cause an increase in the hydrostatic pressure in the capillaries of the affected leg. This is because the blood that would normally flow through the vein is blocked, causing it to back up and increase the pressure in the capillaries. This increased hydrostatic pressure pushes more fluid out of the capillaries and into the surrounding tissues.

At the same time, the blood clot can also cause a decrease in the oncotic pressure in the capillaries. This is because the clot can prevent proteins in the blood from reaching the capillaries, reducing the osmotic pressure that would normally pull fluid back into the capillaries from the tissues.

The combination of increased hydrostatic pressure and decreased oncotic pressure disrupts the balance of the Starling forces, leading to an accumulation of fluid in the tissues, which is known as oedema. This is why Julia's right leg is red and considerably swollen.

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