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Astronaut on the International Space Station (ISS) follow strict training and exercise regimes. Despite these training regimes, there is still noticeable change in the heart with a reduction in Heart Mass, including left ventricular mass, and enlarged left atrium. Which of the following are plausible contributing factors, and/or explanation for the observed changes in cardiac morphology?(select all that are correct, even if it is only one answer)Each correct answer will score partial points, each incorrect answer will score an equivalent deductionGroup of answer choicesThe lack of gravity directly affects cardiac myocytes resulting in atrophyThe lack of exercise results in less cardiac work loadThe observed reduction in systemic vascular resistance = lower afterloadThe lack of gravitational effect results in a lower afterload on the heart

Question

Astronaut on the International Space Station (ISS) follow strict training and exercise regimes. Despite these training regimes, there is still noticeable change in the heart with a reduction in Heart Mass, including left ventricular mass, and enlarged left atrium. Which of the following are plausible contributing factors, and/or explanation for the observed changes in cardiac morphology?(select all that are correct, even if it is only one answer)Each correct answer will score partial points, each incorrect answer will score an equivalent deductionGroup of answer choicesThe lack of gravity directly affects cardiac myocytes resulting in atrophyThe lack of exercise results in less cardiac work loadThe observed reduction in systemic vascular resistance = lower afterloadThe lack of gravitational effect results in a lower afterload on the heart

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Solution

The correct answers are:

  1. The lack of gravity directly affects cardiac myocytes resulting in atrophy: This is correct because in the absence of gravity, the heart doesn't have to work as hard to pump blood throughout the body, which can lead to atrophy of the cardiac muscle cells.

  2. The observed reduction in systemic vascular resistance = lower afterload: This is also correct. In space, the lack of gravity can cause a reduction in systemic vascular resistance, which means the heart doesn't have to work as hard to pump blood, leading to a lower afterload.

  3. The lack of gravitational effect results in a lower afterload on the heart: This is correct for the same reasons as the previous answer. The lack of gravity reduces the afterload on the heart, which can lead to changes in the heart's structure.

The lack of exercise results in less cardiac work load: This is not correct. Astronauts on the ISS follow strict exercise regimes to help counteract the effects of living in microgravity, so lack of exercise is not a contributing factor to the changes in cardiac morphology.

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