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The resting membrane potential of intestinal epithelial cells is approximately -70 mV, which means that the electric potential of the cytosolic surface of the plasma membrane is approximately 70 mV more negative than that of the outer extracellular surface of the plasma membrane. Suppose that the intestinal cell membrane became suddenly permeable to sodium ions. Which of the following is MOST likely to occur as a result? A.There will be a net flux of sodium ions into the cell.B.There will be a net flux of sodium ions out of the cell.C.There will be no net flux of sodium ions into or out of the cell.D.It is impossible to determine with the information given.

Question

The resting membrane potential of intestinal epithelial cells is approximately -70 mV, which means that the electric potential of the cytosolic surface of the plasma membrane is approximately 70 mV more negative than that of the outer extracellular surface of the plasma membrane. Suppose that the intestinal cell membrane became suddenly permeable to sodium ions. Which of the following is MOST likely to occur as a result? A.There will be a net flux of sodium ions into the cell.B.There will be a net flux of sodium ions out of the cell.C.There will be no net flux of sodium ions into or out of the cell.D.It is impossible to determine with the information given.

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Solution

The most likely outcome is A. There will be a net flux of sodium ions into the cell. This is because sodium ions are more concentrated outside the cell than inside. If the membrane becomes permeable to sodium ions, they will move down their concentration gradient from an area of high concentration (outside the cell) to an area of low concentration (inside the cell). This is a process known as passive diffusion.

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