A 43-year-old woman comes to the office due to lower extremity edema that has developed over the last 2 weeks. She has no cough, shortness of breath, chest pain, or leg pain. Medical history is significant for diet-controlled type 2 diabetes mellitus and hypertension. Her antihypertensive regimen was recently adjusted to improve blood pressure control. Blood pressure is 133/80 mm Hg and BMI is 27 kg/m2. Physical examination shows bilateral pedal edema but is otherwise unremarkable. Which of the following is most likely responsible for this patient's symptoms? A.Amlodipine B.Hydrochlorothiazide C.Losartan D.Metoprolol E.Ramipril
Question
A 43-year-old woman comes to the office due to lower extremity edema that has developed over the last 2 weeks. She has no cough, shortness of breath, chest pain, or leg pain. Medical history is significant for diet-controlled type 2 diabetes mellitus and hypertension. Her antihypertensive regimen was recently adjusted to improve blood pressure control. Blood pressure is 133/80 mm Hg and BMI is 27 kg/m2. Physical examination shows bilateral pedal edema but is otherwise unremarkable. Which of the following is most likely responsible for this patient's symptoms? A.Amlodipine B.Hydrochlorothiazide C.Losartan D.Metoprolol E.Ramipril
Solution
The most likely cause of this patient's symptoms is Amlodipine. Amlodipine is a calcium channel blocker used to treat high blood pressure. One of the common side effects of Amlodipine is peripheral edema (swelling in the feet and ankles). This is due to the fact that Amlodipine can cause vasodilation, or the widening of blood vessels, which can lead to fluid accumulation in the lower extremities. The patient's recent adjustment of her antihypertensive regimen and the absence of other symptoms such as cough, shortness of breath, chest pain, or leg pain further support Amlodipine as the most likely cause of her lower extremity edema.
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