Which of the following two statements correctly describes the behavior of the haemoglobin protein HbS in sickle-cell disease?Question 9Select one or more:a.The haemoglobin protein lacks a haem group.b.The haemoglobin protein dissociates into four subunits.c.Neighbouring haemoglobin proteins aggregate together.d.Caused by a change in the amino acid sequence in haemoglobin.e.The haemoglobin protein possesses an iron atom in the Fe (III) form rather than the normal Fe (II) form.f.Caused by a protein deficiency.
Question
Which of the following two statements correctly describes the behavior of the haemoglobin protein HbS in sickle-cell disease?Question 9Select one or more:a.The haemoglobin protein lacks a haem group.b.The haemoglobin protein dissociates into four subunits.c.Neighbouring haemoglobin proteins aggregate together.d.Caused by a change in the amino acid sequence in haemoglobin.e.The haemoglobin protein possesses an iron atom in the Fe (III) form rather than the normal Fe (II) form.f.Caused by a protein deficiency.
Solution
The correct statements that describe the behavior of the haemoglobin protein HbS in sickle-cell disease are:
c. Neighbouring haemoglobin proteins aggregate together. This is true because in sickle cell disease, the abnormal hemoglobin molecules tend to stick together when the blood's oxygen levels decrease, forming long, rod-like structures. These structures cause red blood cells to become stiff, assuming a sickle shape.
d. Caused by a change in the amino acid sequence in haemoglobin. This is also true. Sickle cell disease is caused by a mutation in the gene that instructs the body to make hemoglobin. Specifically, it's a point mutation where the amino acid valine replaces the normal amino acid glutamic acid. This small change in the protein sequence causes the hemoglobin to behave differently, leading to the symptoms of sickle cell disease.
The other statements are not correct in the context of sickle cell disease.
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