The threonine to isoleucine pathway is an example of how metabolic pathways can be regulated bya. allosteric activatorsb. allosteric inhibitorsc. competitive inhibitorsd. irreversible inhibitorse. none of the above
Question
The threonine to isoleucine pathway is an example of how metabolic pathways can be regulated bya. allosteric activatorsb. allosteric inhibitorsc. competitive inhibitorsd. irreversible inhibitorse. none of the above
Solution
The threonine to isoleucine pathway is an example of how metabolic pathways can be regulated by allosteric inhibitors.
Here's a step-by-step explanation:
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Threonine is converted to isoleucine in a series of enzymatic reactions.
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The first enzyme in this pathway, threonine deaminase, is inhibited by isoleucine.
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This is an example of feedback inhibition, a type of allosteric regulation.
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In feedback inhibition, the end product of a metabolic pathway (in this case, isoleucine) binds to an enzyme that acts early in the pathway (threonine deaminase), reducing the enzyme's activity.
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This binding often occurs at a site on the enzyme separate from the active site, which is why it's called allosteric ("other site") regulation.
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By inhibiting the enzyme, isoleucine prevents its own synthesis when its levels are high, thus efficiently regulating the pathway.
So, the correct answer is b. allosteric inhibitors.
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