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Number of ATP generated via oxidative phosphorylation

Question

Number of ATP generated via oxidative phosphorylation

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Solution

To determine the number of ATP generated via oxidative phosphorylation, we need to follow these steps:

  1. Understand the process of oxidative phosphorylation: Oxidative phosphorylation is the final step in cellular respiration, where electrons from NADH and FADH2 are transferred through a series of protein complexes in the electron transport chain (ETC). This transfer of electrons creates a proton gradient across the inner mitochondrial membrane.

  2. Determine the number of ATP generated per NADH and FADH2: During oxidative phosphorylation, each NADH molecule generates approximately 2.5 ATP, while each FADH2 molecule generates approximately 1.5 ATP.

  3. Calculate the number of NADH and FADH2 molecules produced: The number of NADH and FADH2 molecules produced during cellular respiration depends on the specific pathway used (glycolysis, pyruvate oxidation, and the citric acid cycle). For example, in the citric acid cycle, each glucose molecule produces 6 NADH and 2 FADH2.

  4. Multiply the number of NADH and FADH2 molecules by the ATP yield: Multiply the number of NADH molecules by 2.5 ATP and the number of FADH2 molecules by 1.5 ATP. Then, sum up the total ATP generated from both NADH and FADH2.

  5. Add the ATP generated from glycolysis and the citric acid cycle: In addition to ATP generated via oxidative phosphorylation, ATP is also produced during glycolysis (2 ATP) and the citric acid cycle (2 ATP). Add these ATP molecules to the total calculated in step 4.

  6. Calculate the final number of ATP generated: Sum up the ATP generated from oxidative phosphorylation, glycolysis, and the citric acid cycle to determine the total number of ATP molecules generated via oxidative phosphorylation.

By following these steps, you can determine the number of ATP generated via oxidative phosphorylation.

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