Which of the following statements is/are true about the Pyruvate Dehydrogenase Complex (PDC)?Group of answer choicesA) Lipoate has a disulfide bond which is reduced during the course of the enzymatic reactions of the PDCB) CoenzymeA has a direct role in the decarboxylation of pyruvate and is covalently attached to the enzyme it works with.C) The PDC reaction is highly endergonic, so it requires the hydrolysis of ATP.D) The series of steps in the PDC ends with the creation of Acetyl CoA.E) All of the above are true.
Question
Which of the following statements is/are true about the Pyruvate Dehydrogenase Complex (PDC)?Group of answer choicesA) Lipoate has a disulfide bond which is reduced during the course of the enzymatic reactions of the PDCB) CoenzymeA has a direct role in the decarboxylation of pyruvate and is covalently attached to the enzyme it works with.C) The PDC reaction is highly endergonic, so it requires the hydrolysis of ATP.D) The series of steps in the PDC ends with the creation of Acetyl CoA.E) All of the above are true.
Solution
The correct answer is both A and D.
A) Lipoate does indeed have a disulfide bond which is reduced during the enzymatic reactions of the PDC. This is part of the process that allows the PDC to function and carry out its role in cellular respiration.
D) The series of steps in the PDC does indeed end with the creation of Acetyl CoA. This molecule is crucial for the next step in cellular respiration, the citric acid cycle.
B) CoenzymeA does not have a direct role in the decarboxylation of pyruvate and is not covalently attached to the enzyme it works with. Instead, it acts as a carrier for acetyl groups in the PDC.
C) The PDC reaction is not highly endergonic, it does not require the hydrolysis of ATP. In fact, it is an exergonic reaction, meaning it releases energy.
So, the statement E) All of the above are true is incorrect.
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