Which statement about the production of pyruvate in the final step of glycolysis is CORRECT? A. Pyruvate kinase transfers a phosphate group from ATP to PEP to generate pyruvate and ADP. B. The unfavourable conversion of PEP to pyruvate is driven largely by the highly favourable standard free energy change for the hydrolysis of ATP to ADP. C. The standard free energy change for the conversion of PEP to pyruvate is very highly favourable to counteract the unfavourable phosphorylation of ADP to ATP.
Question
Which statement about the production of pyruvate in the final step of glycolysis is CORRECT? A. Pyruvate kinase transfers a phosphate group from ATP to PEP to generate pyruvate and ADP. B. The unfavourable conversion of PEP to pyruvate is driven largely by the highly favourable standard free energy change for the hydrolysis of ATP to ADP. C. The standard free energy change for the conversion of PEP to pyruvate is very highly favourable to counteract the unfavourable phosphorylation of ADP to ATP.
Solution
The correct statement is C. The standard free energy change for the conversion of PEP to pyruvate is very highly favourable to counteract the unfavourable phosphorylation of ADP to ATP.
Here's why:
A. This statement is incorrect. Pyruvate kinase transfers a phosphate group from PEP (Phosphoenolpyruvate) to ADP (Adenosine diphosphate) to generate pyruvate and ATP (Adenosine triphosphate), not from ATP to PEP.
B. This statement is also incorrect. The conversion of PEP to pyruvate is actually a favourable reaction, not an unfavourable one. It does not need to be driven by the hydrolysis of ATP to ADP.
C. This statement is correct. The conversion of PEP to pyruvate is a highly exergonic (energy-releasing) reaction. This means it has a very negative standard free energy change, making it a favourable reaction. This energy is used to counteract the unfavourable phosphorylation of ADP to ATP, which is an endergonic (energy-requiring) reaction.
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