Which one of the following statements about dependence-producing drugs is correct?Group of answer choicesThey work by blocking the reuptake of acetylcholine.Sensitivity to their euphoric effects will increase following repetitive drug taking.They increase dopaminergic signalling in the mesolimbic pathway.Animals will not self-administer these drugs in behavioural studies.
Question
Which one of the following statements about dependence-producing drugs is correct?Group of answer choicesThey work by blocking the reuptake of acetylcholine.Sensitivity to their euphoric effects will increase following repetitive drug taking.They increase dopaminergic signalling in the mesolimbic pathway.Animals will not self-administer these drugs in behavioural studies.
Solution
The correct statement about dependence-producing drugs is: "They increase dopaminergic signalling in the mesolimbic pathway."
Here's why:
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Dependence-producing drugs do not work by blocking the reuptake of acetylcholine. They typically work by increasing the release or blocking the reuptake of other neurotransmitters like dopamine, serotonin, or norepinephrine.
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Sensitivity to the euphoric effects of these drugs does not increase with repetitive drug taking. In fact, the opposite is true. With repeated use, individuals often develop a tolerance to the drug, meaning they require larger doses to achieve the same effect.
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Dependence-producing drugs do increase dopaminergic signalling in the mesolimbic pathway. This pathway is involved in reward, and increased signalling here is thought to contribute to the addictive properties of these drugs.
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Animals will self-administer these drugs in behavioural studies. This is one of the key tests used in research to determine whether a substance has addictive potential.
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