Which of the following statements regarding T cell function is correct?A TCR on a mature T lymphocyte must be able to bind to self MHC.T cell development takes place in the bone marrow.MHC molecules are not involved in positive selection.A CD4 T cell can interacts with any cells with class I MHC.
Question
Which of the following statements regarding T cell function is correct?A TCR on a mature T lymphocyte must be able to bind to self MHC.T cell development takes place in the bone marrow.MHC molecules are not involved in positive selection.A CD4 T cell can interacts with any cells with class I MHC.
Solution 1
The correct statement regarding T cell function is "A TCR on a mature T lymphocyte must be able to bind to self MHC."
Here's why:
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TCR (T cell receptor) on a mature T lymphocyte must be able to bind to self MHC (Major Histocompatibility Complex): This is correct. TCRs must be able to recognize and bind to self MHC molecules for the T cell to function properly. This is a crucial part of the immune response.
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T cell development takes place in the bone marrow: This is incorrect. While T cells originate in the bone marrow, they mature in the thymus, which is where they develop their TCRs.
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MHC molecules are not involved in positive selection: This is incorrect. MHC molecules are crucial for positive selection, which is the process by which T cells that can bind to self MHC molecules are selected to mature.
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A CD4 T cell can interact with any cells with class I MHC: This is incorrect. CD4 T cells interact with class II MHC molecules, not class I. CD8 T cells are the ones that interact with class I MHC molecules.
Solution 2
The correct statement regarding T cell function is "A TCR on a mature T lymphocyte must be able to bind to self MHC."
Here's why:
-
TCR (T cell receptor) on a mature T lymphocyte must be able to bind to self MHC (Major Histocompatibility Complex): This is correct. TCRs must be able to recognize and bind to self MHC molecules for the T cell to function properly. This is a crucial part of the immune response.
-
T cell development takes place in the bone marrow: This is incorrect. While T cells originate in the bone marrow, they mature in the thymus, which is where they develop their TCRs.
-
MHC molecules are not involved in positive selection: This is incorrect. MHC molecules are crucial for positive selection, which is the process by which T cells that can bind to self MHC molecules are selected to mature.
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A CD4 T cell can interact with any cells with class I MHC: This is incorrect. CD4 T cells interact with class II MHC molecules, not class I. CD8 T cells are the ones that interact with class I MHC molecules.
Similar Questions
Which statement is TRUE about the CD4 subset of T cells?Select one alternative:They recognise peptides presented by MHC class I.They recognise peptides presented by MHC class II.They kill cells that have phagocytosed bacteria.They kill virally infected cells.
Class I MHC molecule can ____________.bind to CD8 molecules on T cellspresent antigens to B cellsbind to CD4 molecules on T cellsbind to antibodies
__________ are the most abundant T cells, and their function is to __________.ANSWERT helper cells (CD4+); activate B cells to stimulate the humoral branch of adaptive immunityT cytotoxic cells (CD8+); directly destroy cells that are virus-infectedT helper cells (CD4+); coordinate the adaptive immune responseT cytotoxic cells (CD8+); seek and destroy cancer cells
Compared to the MHC molecule on the left, the MHC molecule on the right (in the drawing above) will bind a ______ peptide that, if foreign, will cause a T cell to activate and _________. The protein on the left is made up of two peptides, each with two domains. One peptide has domains labeled alpha 1 and 2, the other beta 1 and 2. The protein on the right is made up of two peptides, one with three domains labeled alpha 1, 2 and 3 and the other a single domain labeled beta MG.
Which of the following are mediated by antigen-specific T-cells and nonspecific cells of the immune system?
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