Which of the following are mediated by antigen-specific T-cells and nonspecific cells of the immune system?

I'm sorry, but you didn't provide a list of options or a specific context for your question. However, I can tell you that antigen-specific T-cells and nonspecific cells of the immune system mediate several immune responses.

1. Cell-Mediated Immunity: This is primarily carried out by T-cells. When a pathogen invades the body, antigen-presenting cells (APCs) such as macrophages and dendritic cells capture the pathogen's antigens and present them to T-cells. This triggers the T-cells to proliferate and differentiate into effector T-cells, which can directly kill infected cells or help other immune cells respond to the pathogen.

2. Cytokine Production: Both antigen-specific T-cells and nonspecific immune cells like macrophages and natural killer cells can produce cytokines. These are signaling molecules that modulate the immune response, promoting inflammation, cell proliferation, and cell death as needed.

3. Inflammation: Nonspecific immune cells like neutrophils and macrophages are key players in inflammation, a response that helps isolate and destroy pathogens. T-cells can also contribute to inflammation through cytokine production.

4. Immunological Memory: After an infection, some T-cells become memory T-cells. These cells can quickly recognize and respond to the same antigen if it is encountered again, providing long-term immunity.

5. Hypersensitivity Reactions: These are excessive immune responses that can cause tissue damage.