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A parkinson disease patient states that her symptoms seem worse before her next dose of carbidopa/levodopa. Which agent would best be added?Question 37Answera.Apomorphineb.Quetiapinec.Istradefyllined.Entacapone

Question

A parkinson disease patient states that her symptoms seem worse before her next dose of carbidopa/levodopa. Which agent would best be added?Question 37Answera.Apomorphineb.Quetiapinec.Istradefyllined.Entacapone

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Solution

The best agent to be added for a Parkinson's disease patient who states that her symptoms seem worse before her next dose of carbidopa/levodopa would be Entacapone.

Entacapone is a type of drug known as a COMT inhibitor. It works by prolonging the effects of levodopa therapy by blocking an enzyme that breaks down levodopa in the body. This allows for a more steady, consistent level of levodopa in the brain, which can help to smooth out the fluctuations in motor symptoms that the patient is experiencing.

Here's the step-by-step reasoning:

  1. The patient is experiencing a worsening of symptoms before her next dose of carbidopa/levodopa, which suggests that the effects of the levodopa are wearing off too soon.

  2. Entacapone can help to prolong the effects of levodopa by preventing its breakdown in the body.

  3. Therefore, adding entacapone to the patient's treatment regimen could help to maintain a more consistent level of levodopa in the brain, reducing the fluctuations in symptoms that the patient is experiencing.

Please note that any changes to medication should be done under the supervision of a healthcare provider.

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