A mutation denoted as : p.Gly551Asp can also be denoted as :c.551G>AG551Dp.Gly551p.Asp551Gly
Question
A mutation denoted as : p.Gly551Asp can also be denoted as :c.551G>AG551Dp.Gly551p.Asp551Gly
Solution
The mutation p.Gly551Asp refers to a change in the protein sequence where the amino acid glycine (Gly) at position 551 is replaced by aspartic acid (Asp).
This can also be denoted in several other ways:
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c.551G>A: This notation is used to indicate changes at the DNA level. The "c." stands for "coding DNA sequence". Here, it means that the guanine (G) at position 551 is replaced by adenine (A).
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G551D: This is a simplified version of the protein-level notation. It simply means that glycine (G) at position 551 is replaced by aspartic acid (D).
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p.Gly551: This notation refers to the original amino acid (glycine) at position 551 in the protein sequence.
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p.Asp551: This notation refers to the new amino acid (aspartic acid) at position 551 in the protein sequence after the mutation.
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Gly551Asp: This is another simplified version of the protein-level notation. It simply means that glycine (Gly) at position 551 is replaced by aspartic acid (Asp).
Similar Questions
A mutation that results in a G replaced by an T, 3 base pairs before the start of an exon is denoted as :NM_000492.3:c.489+3G>TNM_000492.3:c.489/486G>TNM_000492.3:c.489-3G>TNM_000492.3:c.489G>T
A mutation written as : c.76A>C denotes :nucleotide 76 C is changed to a Anucleotide 76 A is changed to a Camino acid 76 is changed from A to Cthere are 76 more As than Cs in the DNA
The original strand of DNA looks like this ACGTCTCGA. The mutated strand looks like this ACGTTCGA. What type of mutation is this?*1 pointTranslocationNucleotide base deletionNucleotide base insertionNucleotide base substitution
The mutation c.546delT is :nucleotide T is deleted from cDNA position 546duplication of T at 546codon 546 has become TTTamino acid T is deleted from position 546
Identify the mutation type in the figure below.substitutioninversiontranslocationdeletion
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