How does histone acetylation activate transcription in eukaryotes?Group of answer choicesby increasing the affinity of histone for DNAby recruiting other components of the transcriptional machineryby inhibiting the active remodeling of the chromatin structureall of the abovenone of the above
Question
How does histone acetylation activate transcription in eukaryotes?Group of answer choicesby increasing the affinity of histone for DNAby recruiting other components of the transcriptional machineryby inhibiting the active remodeling of the chromatin structureall of the abovenone of the above
Solution
Histone acetylation activates transcription in eukaryotes through a series of steps. Here is a step-by-step explanation:
- Histone acetylation refers to the addition of acetyl groups to the histone proteins that make up the chromatin structure.
- Acetylation neutralizes the positive charge of the histones, which reduces their affinity for the negatively charged DNA.
- By decreasing the affinity of histones for DNA, acetylation allows for easier access of the transcriptional machinery to the DNA.
- This increased accessibility facilitates the recruitment of other components of the transcriptional machinery, such as transcription factors and RNA polymerase.
- These recruited components can then bind to specific DNA sequences and initiate the transcription process.
- Additionally, histone acetylation can also inhibit the active remodeling of the chromatin structure, preventing the formation of compacted chromatin and allowing for transcriptional activation.
- Therefore, histone acetylation activates transcription by increasing the affinity of histone for DNA, recruiting other components of the transcriptional machinery, and inhibiting the active remodeling of the chromatin structure.
- The correct answer is "all of the above."
Similar Questions
What is the effect of high levels of histone acetylation on the expression of a gene?Group of answer choicesThis changes the splicing of the geneIt causes the chromatin to condenseThe gene becomes expressed lessThe gene becomes expressed more
Which of the following is (are) associated with the activation of transcription?Group of answer choicesChromatin remodeling.Histone acetylation.RNA polymerase recruited to the promoter.Transcription factors recruited to the (eukaryotic) promoter.All of the above.
Histone proteins can be modified through methlyation, acetylation, and phosphorylation. Most oftenit is lysine (K) amino acids that are modified. To investigate the role of the acetylation of a lysine atposition 56 (K56) in histone H3, a mutation was made where the lysine is replaced with an arginineresidue, which prevents acetylation. This mutation is lethal at the embryonic stage.a. What effect would this mutation have on the packing of chromatin? Explain your answer. (2marks)b. What could be the reason that this mutation is lethal? Suggest a reason and explain yourchoice. (3 marks)Questions continue over the page.
Increase in histone deacetylases.B. Increase in histone acetyltransferases.C. Decrease in DNA methyltransferases.D. Decrease in CpG methylation of promoter
Affects of acetylation on histones (lysine)?Select your answer:Select your answerOPTION ALTERNATIVE Adding acetyl group to the end of the histone makes it negative makes the DNA that its associated with more readily transcribed Removes positive charge from the side-chain so weakens the interaction between histones and negatively charged DNA. All of the above
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