Select the reasons to conduct pre-clinical trials.

Pre-clinical trials are conducted for several important reasons:

1. Safety Assessment: One of the primary reasons for conducting pre-clinical trials is to assess the safety of a new drug or treatment. This involves testing the drug on non-human subjects to understand its effects and identify any potential risks or side effects.

2. Efficacy Evaluation: Pre-clinical trials also help in evaluating the efficacy of a drug. This means determining whether the drug produces the desired results.

3. Dosage Determination: These trials help in determining the appropriate dosage of the drug. This is crucial to ensure that the drug is effective while also minimizing any potential side effects.

4. Mechanism of Action: Pre-clinical trials can help in understanding the mechanism of action of a drug, i.e., how the drug works at the molecular level.

5. Metabolism and Pharmacokinetic Studies: These trials also involve studies to understand how the drug is absorbed, distributed, metabolized, and excreted from the body.

6. Toxicology Studies: Pre-clinical trials also include toxicology studies to understand the impact of the drug on various organ systems and to identify any potential toxicity.

Remember, the goal of pre-clinical trials is to gather as much information as possible about a drug before it is tested on humans. This is crucial to ensure the safety and effectiveness of the drug.