Protein Science - Topic Selection Protein Science Topics Below is a list of four topics and a short explanation of the content of each topic. Read each topic carefully and maybe research the topic yourself, then select the topic you would like to study. Lecture recordings, lecture notes and workshop questions for each topic will be available on the Learning@Griffith website Prior to week 9. The task of selecting your topic must be completed by Sunday 11:59 pm of week 5 (Sunday 14th April). Topic 1: Proteomics Proteomics is the study of the complete collection of proteins within a cell/tissue/organism at a specific time. The study of proteins includes understanding the structures of all proteins, their roles in cells, the molecules with which they interact and how much is present at a particular time. This topic will cover an introduction to proteomics and some of the techniques used, as well as how proteomics can be used in research to study disease. Topic 2: Protein Engineering Protein engineering can be used to alter a protein at the molecular level to improve or change its function. This topic will cover the strategies used to engineer proteins, the specific techniques required to alter the amino acid sequence at the molecular level, and use specific examples to explore how the changes in the structure improve or alter protein function. Topic 3: Protein-DNA Interactions Many proteins play important roles in regulation and metabolism of nucleic acids (DNA and RNA). In order to perform the processes of DNA replication, transcription and gene regulation, proteins must specifically interact with nucleic acids. This topic will investigate structural motifs of protein that allow them to specifically interact with DNA. The 3-dimensional structure of DNA binding motifs will be explored as well as the structure of DNA in order to understand how an amino acid sequence of a protein can recognise and bind to a specific DNA sequence. Topic 4: Protein Therapies Proteins are increasingly being used as therapies for the treatment of medical conditions. Since the introduction of insulin about 25 years ago there are now some 130 protein used in therapeutics although their role in medicine is only in its infancy. This topic will explore the effectiveness of proteins as therapeutics and investigate the structure and function of therapeutic proteins used for the treatment of specific diseases. Topic Choice for Module 5 (weeks 10 &11) Choose the topic you would like to learn for Module 5. 1. Proteomics 2. Protein Engineering 3. Protein-DNA Interactions 4. Protein Therapies Comment on why you chose this topic. ​​​​​​Write your comment below. I chose protein engineering as my topic of interest because I would like to understand how specific techniques are used in protein engineering to alter the amino acid sequences at a molecular level and how these modifications improve and change protein functions. Furthermore, I look forward to exploring the p