The antibody test that would provide both high specificity and correlate with disease activity when considering a diagnosis of systemic lupus erythematosus (SLE) is c) Anti-dsDNA.

Here's why:

a) ANA (Antinuclear Antibody) - This is a sensitive test but not specific. It can be positive in many autoimmune diseases, not just SLE.

b) Anti-RNP (Anti-Ribonucleoprotein) - This is more specific for mixed connective tissue disease.

c) Anti-dsDNA (Anti-double stranded DNA) - This is both highly specific for SLE and correlates with disease activity. When the disease is more active, levels of anti-dsDNA will be higher.

d) Anti-Smith - This is specific for SLE but does not correlate with disease activity.

e) Antihistone - These antibodies are more commonly seen in drug-induced lupus, not SLE.

Question

The antibody test that would provide both high specificity and correlate with disease activity when considering a diagnosis of systemic lupus erythematosus (SLE) is c) Anti-dsDNA.

Here's why:

a) ANA (Antinuclear Antibody) - This is a sensitive test but not specific. It can be positive in many autoimmune diseases, not just SLE.

b) Anti-RNP (Anti-Ribonucleoprotein) - This is more specific for mixed connective tissue disease.

c) Anti-dsDNA (Anti-double stranded DNA) - This is both highly specific for SLE and correlates with disease activity. When the disease is more active, levels of anti-dsDNA will be higher.

d) Anti-Smith - This is specific for SLE but does not correlate with disease activity.

e) Antihistone - These antibodies are more commonly seen in drug-induced lupus, not SLE.

Knowee AI · Accepted Answer

The antibody test that would provide both high specificity and correlate with disease activity when considering a diagnosis of systemic lupus erythematosus (SLE) is c) Anti-dsDNA.

Here's why:

a) ANA (Antinuclear Antibody) - This is a sensitive test but not specific. It can be positive in many autoimmune diseases, not just SLE.

b) Anti-RNP (Anti-Ribonucleoprotein) - This is more specific for mixed connective tissue disease.

c) Anti-dsDNA (Anti-double stranded DNA) - This is both highly specific for SLE and correlates with disease activity. When the disease is more active, levels of anti-dsDNA will be higher.

d) Anti-Smith - This is specific for SLE but does not correlate with disease activity.

e) Antihistone - These antibodies are more commonly seen in drug-induced lupus, not SLE.

When considering a diagnosis of systemic lupuserythematosus (SLE), which antibody test wouldprovide both high specificity and correlate withdisease activity?a) ANAb) Anti-RNPc) Anti-dsDNAd) Anti-Smithe) Antihistone

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