NSAIDs can be used initially and are effective in reducing pain and swelling of the joints. Which of the following actions best explains why NSAIDs can reduce swelling of the joints?Question 2Answera.Inhibition of platelet aggregationb.Increased margination of neutrophilsc.Decreased synthesis of IL-1 and IL-2d.Decreased blood flow in the inflamed areae.Increased renal blood flow
Question
NSAIDs can be used initially and are effective in reducing pain and swelling of the joints. Which of the following actions best explains why NSAIDs can reduce swelling of the joints?Question 2Answera.Inhibition of platelet aggregationb.Increased margination of neutrophilsc.Decreased synthesis of IL-1 and IL-2d.Decreased blood flow in the inflamed areae.Increased renal blood flow
Solution
NSAIDs, or nonsteroidal anti-inflammatory drugs, work by inhibiting the production of substances in the body called prostaglandins, which play a key role in pain and inflammation. Prostaglandins are produced by the enzyme cyclooxygenase (COX). There are two types of COX: COX-1, which protects the stomach lining, and COX-2, which is produced in response to injury or inflammation.
NSAIDs work by blocking the COX enzymes, reducing the production of prostaglandins. This results in a decrease in inflammation and pain. Therefore, the action that best explains why NSAIDs can reduce swelling of the joints is:
c. Decreased synthesis of IL-1 and IL-2
IL-1 and IL-2 are types of cytokines, which are proteins that play a crucial role in cell signaling during immune responses. They are involved in the inflammation process, so by decreasing their synthesis, NSAIDs can effectively reduce inflammation and swelling.
Similar Questions
2. NSAIDs relieve pain by:Group of answer choicesA. Blocking pain receptors in the brainB. Blocking transmission of nerve impulses in the spinal cordC. Inhibiting prostaglandin synthesisD. Inhibiting arachidonic acid synthesisE. None of the above
What pharmacological agent serves to reduce inflammation for people with chronic inflammatory disease? A. cholinergic muscle stimulants B. antispasmodics C. opioid analgesics D. corticosteroids E. aspirin
What is the role of inflammation in response to damage?A. Increases mucosal secretions at the siteB. Fights pathogens that enter the bodyC. Provides a barrier for tissue from the outside environmentD. Creates swelling to help protect the site of damage
By using an NSAID to reduce inflammation, what other physiological processes may be affected by blocking prostaglandin synthesis?
Select all that applyWhich events occur during inflammation?Multiple select question.Swelling occurs.Blood vessels constrict.Blood flow to the site decreases.Capillary permeability increases.
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