Which of the following statements is true about surrogate endpoints?Question 5Select one:a.Are only used in studies that have mortality as an outcomeb.They prolong the time taken to complete the studyc.They cannot be used to measure secondary outcomesd.They capture a clinical endpoint, without actually measuring it
Question
Which of the following statements is true about surrogate endpoints?Question 5Select one:a.Are only used in studies that have mortality as an outcomeb.They prolong the time taken to complete the studyc.They cannot be used to measure secondary outcomesd.They capture a clinical endpoint, without actually measuring it
Solution
The correct answer is:
d. They capture a clinical endpoint, without actually measuring it
Explanation: Surrogate endpoints are used in clinical trials as a measure of effect of a certain treatment that may correlate with a real clinical endpoint but does not necessarily have a guaranteed relationship. They are often used when the primary endpoint is undesired (e.g., death), or when the number of events is very small, thus making it impractical to conduct a clinical trial to gather a statistically significant number of endpoints. The surrogate endpoint needs to be a true predictor of the real endpoint.
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