Dose-response data was collected during the testing of drugs A and B. Drug B markedly decreases the efficacy of drug A and even increases the dose of drug A, So, drug B is:a.Non-competitive antagonistb.Partial agonistc.Inverse agonistd.Competitive antagonist

Competitive antagonist differs from non-competitive in all the following except:a.It modifies drug potency, not efficacyb.Its effect can be reversed by increasing the dose of the agonistc.It reduces the maximal agonist response even with increasing the dosed.Shift the dose-response curve of the agonist to the right

Determine the CORRECT terms used in drug-receptor interactions with the appropriate responses. A. Difference in intrinsic abilities of two drugs bound to the same receptor to elicit an the effect is the Relative Potency. TRUE/FALSE B. Relative Affinity shows the relative position of drugs along the dose-response curve axis. TRUE/FALSE C. The comparison of the amount that causes therapeutic effect to the amount that causes toxicity is the Therapeutic Index. TRUE/FALSE D. Relative Efficacy determines the concentration of drug required to produce a certain degree of rightward shift in the presence of its antagonist. TRUE/FALSE E. Therapeutic Window is used to define limits of drug concentrations that provide therapeutic efficacy with minimal toxicity. TRUE/FALSE

A drug that binds to a receptor and produces a biological response that mimics the response to the endogenous ligand is known as* (A) Agonist (B) Antagonist (C) Functional antagonist (D) Partial agonist (E) Partial antagonist

Dose-response curves can be used to: A. determine if a drug produces a certain desired effect TRUE/FALSE B. estimate the relative safety of a drug TRUE/FALSE C. compare a particular drug with its congeners TRUE/FALSE D. determine the dose required to produce effect by a drug TRUE/FALSE E. assess the efficacy and effectiveness of drugs TRUE/FALSE

The substance binding to one receptor subtype as an agonist and to another as an antagonist is called:a.Competitive antagonistb.Partial agonistc.Agonist-antagonistd.Irreversible antagonist