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13. Drugs that are                        bound or                        cannot cross the BBB. 14.                        is defined as a decreased response occurring during the course of prolonged drug use. 15.                        is defined as a state in which abrupt discontinuation of drug use will precipitate a withdrawal syndrome.

Question

  1. Drugs that are                        bound or                        cannot cross the BBB. 14.                        is defined as a decreased response occurring during the course of prolonged drug use. 15.                        is defined as a state in which abrupt discontinuation of drug use will precipitate a withdrawal syndrome.
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Solution

  1. Drugs that are highly protein bound or lipid insoluble cannot cross the BBB (Blood-Brain Barrier).
  2. Tolerance is defined as a decreased response occurring during the course of prolonged drug use.
  3. Dependence is defined as a state in which abrupt discontinuation of drug use will precipitate a withdrawal syndrome.

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