THE INFLAMMATORY INFILTRATE IN ECZEMA IS PRIMARILY LOCALIZED AROUND
Question
THE INFLAMMATORY INFILTRATE IN ECZEMA IS PRIMARILY LOCALIZED AROUND
Solution
The inflammatory infiltrate in eczema is primarily localized around blood vessels and in the dermis, the layer of skin between the epidermis (outer layer of skin) and subcutaneous tissues.
Here are the steps:
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Inflammation begins: When an allergen or irritant comes into contact with the skin, it triggers an immune response. This causes inflammation, which is the body's way of protecting itself.
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Blood vessels dilate: As part of the immune response, the blood vessels in the skin dilate, or widen. This allows more blood to flow to the area, which brings more immune cells to fight off the allergen or irritant.
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Inflammatory cells infiltrate: Immune cells, such as T cells and mast cells, infiltrate the skin. They release chemicals that cause itching and redness.
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Inflammation is localized: The inflammation is primarily localized around the blood vessels and in the dermis. This is because these are the areas where the immune cells are most active.
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Symptoms appear: The result of this process is the symptoms of eczema, such as redness, itching, and swelling. In some cases, blisters may form and then crust over.
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Healing process: Once the allergen or irritant is removed, the inflammation subsides and the skin begins to heal. However, if the person continues to be exposed to the allergen or irritant, the inflammation can become chronic and the eczema can persist.
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The information in the passage suggests that which characteristic of atopic dermatitis is mediated by B-lymphocytes?A.Joint painB.Prevalence within familiesC.Involvement of both the epidermis and dermisD.Inflammation away from the site of allergen contact
Atopic dermatitis (AD) and contact dermatitis (CD) are two types of inflammatory skin diseases that differ in key characteristics. AD is a chronic condition that commonly affects the skin covering several joints, both exposed to environmental allergens as well as covered by clothing, whereas CD is usually confined to skin that comes into contact with allergens or irritants. AD typically involves the epidermal layer of the skin whereas CD may involve both the epidermis and dermis. Skin affected by AD oozes before becoming chronically dry and scaly; inflammation associated with CD typically resolves within days.Although no cures exist for either AD or CD, management of skin inflammation can be achieved through treatments that suppress inflammation. Multiple factors are thought to contribute to the origin of inflammatory skin diseases, including genetic, immune, and environmental causes. Inflammatory skin disease tends to run in families, a phenomenon that may be related to protein defects. For example, an inherited defect in a structural protein synthesized by keratin-producing epithelial cells is thought to be a key driver of AD.Some research suggests that inflammatory skin disease may be related to a hyperactive immune response. Normally, immune cells discriminate between harmful pathogens and harmless substances. If a harmless molecule that commonly touches the skin causes a response as though the molecule were harmful, further contact may produce an inflammatory response.The hypothesis that modern hygiene plays a role in the development of inflammatory skin disease has also been advanced. For example, frequent hand-washing with soap and water may remove skin oils, leaving the skin more sensitive to common irritants. Question 34Scientists have developed an experimental treatment for inflammatory skin diseases that modifies the activity of certain T-lymphocytes. One function of T-lymphocytes is to:A.present foreign antigen fragments on cell membranes.B.promote a distinct innate immune system response to a specific pathogen.C.secrete signaling molecules that activate other immune cells.D.engulf foreign substances and cellular debris.
Atopic dermatitis (AD) and contact dermatitis (CD) are two types of inflammatory skin diseases that differ in key characteristics. AD is a chronic condition that commonly affects the skin covering several joints, both exposed to environmental allergens as well as covered by clothing, whereas CD is usually confined to skin that comes into contact with allergens or irritants. AD typically involves the epidermal layer of the skin whereas CD may involve both the epidermis and dermis. Skin affected by AD oozes before becoming chronically dry and scaly; inflammation associated with CD typically resolves within days.Although no cures exist for either AD or CD, management of skin inflammation can be achieved through treatments that suppress inflammation. Multiple factors are thought to contribute to the origin of inflammatory skin diseases, including genetic, immune, and environmental causes. Inflammatory skin disease tends to run in families, a phenomenon that may be related to protein defects. For example, an inherited defect in a structural protein synthesized by keratin-producing epithelial cells is thought to be a key driver of AD.Some research suggests that inflammatory skin disease may be related to a hyperactive immune response. Normally, immune cells discriminate between harmful pathogens and harmless substances. If a harmless molecule that commonly touches the skin causes a response as though the molecule were harmful, further contact may produce an inflammatory response.The hypothesis that modern hygiene plays a role in the development of inflammatory skin disease has also been advanced. For example, frequent hand-washing with soap and water may remove skin oils, leaving the skin more sensitive to common irritants. Question 36Presumably, frequent hand-washing leads to skin irritation because:A.chemicals used in soap inhibit the function of neutrophils.B.evaporative cooling of the skin cannot compensate for hand-washing with hot water.C.soap detergents damage immune cells that promote inflammation.D.hand-washing contributes to increased water loss through the skin.
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