elect the drug/combination that you will prescribe as a prophylactic to a resident of non-endemic area who got posted for 6 months to an endemic area with low degree chloroquine resistance among P. falciparum: *1 pointA. QuinineB. Proguanil + ChloroquineC. Pyrimethamine + SulfadoxineD. Artemisinin
Question
elect the drug/combination that you will prescribe as a prophylactic to a resident of non-endemic area who got posted for 6 months to an endemic area with low degree chloroquine resistance among P. falciparum: *1 pointA. QuinineB. Proguanil + ChloroquineC. Pyrimethamine + SulfadoxineD. Artemisinin
Solution
The best option for prophylaxis in a low degree chloroquine-resistant P. falciparum endemic area for a non-resident would be B. Proguanil + Chloroquine.
Here's why:
A. Quinine is not typically used for prophylaxis, but rather for treatment of malaria.
B. Proguanil + Chloroquine is a good choice for prophylaxis in areas with low degree chloroquine resistance. Proguanil works by inhibiting dihydrofolate reductase, which parasites need to replicate and survive. Chloroquine is effective against the parasite stages in the blood that cause the symptoms of malaria.
C. Pyrimethamine + Sulfadoxine is typically used for treatment, not prophylaxis, and is usually reserved for areas with high resistance to other drugs.
D. Artemisinin is a powerful antimalarial drug, but it's not typically used for prophylaxis. It's usually part of a combination therapy for treating malaria, especially in areas with multi-drug resistant strains.
Therefore, the best choice for this scenario would be B. Proguanil + Chloroquine.
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