An adult male living in nonmalarious area has to visit an area where chloroquine resistant P. falciparum is prevalent. He is intolerant to mefloquine and his G6PD status is unknown. Select the drug that you will prescribe for prophylaxis of malaria: *1 pointA. PrimaquineB. DoxycyclineC. AmodiaquineD. Quinine
Question
An adult male living in nonmalarious area has to visit an area where chloroquine resistant P. falciparum is prevalent. He is intolerant to mefloquine and his G6PD status is unknown. Select the drug that you will prescribe for prophylaxis of malaria: *1 pointA. PrimaquineB. DoxycyclineC. AmodiaquineD. Quinine
Solution
The correct answer is B. Doxycycline.
Here's why:
A. Primaquine is not typically used for prophylaxis. It's primarily used for radical cure of P. vivax and P. ovale infections. Also, it can cause hemolysis in people with G6PD deficiency, and since this person's G6PD status is unknown, it's safer not to use it.
B. Doxycycline is a good choice for prophylaxis against chloroquine-resistant P. falciparum. It's also safe to use in people with unknown G6PD status.
C. Amodiaquine is not typically used for prophylaxis. It's primarily used for treatment of acute malaria.
D. Quinine is not typically used for prophylaxis. It's primarily used for treatment of severe malaria.
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