The anti-obesity actions of phentermine are due to:Group of answer choicesan increase in noradrenaline in the synaptic cleft.an increase in lipolysis.an inhibition of gastric emptying.an increase in leptin secretion.
Question
The anti-obesity actions of phentermine are due to:Group of answer choicesan increase in noradrenaline in the synaptic cleft.an increase in lipolysis.an inhibition of gastric emptying.an increase in leptin secretion.
Solution
The anti-obesity actions of phentermine are primarily due to an increase in noradrenaline in the synaptic cleft. Phentermine is a sympathomimetic amine, which means it mimics the action of the sympathetic nervous system. This system is responsible for the body's "fight or flight" response, which includes increasing heart rate and blood pressure, dilating the pupils, and slowing digestion.
Here are the steps explaining how phentermine works:
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Phentermine is taken orally, usually once a day, an hour before or two hours after breakfast.
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Once in the body, phentermine acts as a stimulant, similar to amphetamines. It stimulates neurons to release a group of neurotransmitters known as catecholamines.
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These catecholamines include dopamine, adrenaline (also known as epinephrine), and noradrenaline (norepinephrine).
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The release of these neurotransmitters leads to a decrease in hunger sensations. This is because the brain does not receive the hunger message due to the neurotransmitters blocking the re-uptake of these neurotransmitters.
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Specifically, the increase in noradrenaline in the synaptic cleft is the primary reason for the anti-obesity action of phentermine. Noradrenaline is a neurotransmitter that, when released in the brain, leads to feelings of satiety.
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The result is a decrease in appetite, leading to a decrease in caloric intake, and ultimately, weight loss.
While phentermine may also increase lipolysis (the breakdown of fat), inhibit gastric emptying, and increase leptin secretion, these are not the primary mechanisms by which it promotes weight loss. The main action is the increase in noradrenaline in the synaptic cleft leading to decreased appetite.
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