Which of the following statements best describes leptin?Group of answer choicesA short-term acting peptide hormone synthesised in the stomach that binds to receptors in the hypothalamus to initiate feeding behaviour.A protein that has its levels regulated by feeding status, which results in obesity when overexpressed.A peptide hormone product of the POMC gene that binds to receptors in the paraventricular nucleus to inhibit feeding behaviour.A long-term acting hormone released from adipose tissue that binds to receptors in the hypothalamus to inhibit feeding behaviour.
Question
Which of the following statements best describes leptin?Group of answer choicesA short-term acting peptide hormone synthesised in the stomach that binds to receptors in the hypothalamus to initiate feeding behaviour.A protein that has its levels regulated by feeding status, which results in obesity when overexpressed.A peptide hormone product of the POMC gene that binds to receptors in the paraventricular nucleus to inhibit feeding behaviour.A long-term acting hormone released from adipose tissue that binds to receptors in the hypothalamus to inhibit feeding behaviour.
Solution
Leptin is a hormone that is produced and released by fat cells (adipose tissue). It plays a crucial role in regulating energy intake and energy expenditure, including appetite and metabolism. Leptin acts on receptors in the hypothalamus of the brain where it inhibits hunger by counteracting the effects of neuropeptide Y (a potent feeding stimulant secreted by cells in the gut and in the hypothalamus) and promoting the synthesis of α-MSH, an appetite suppressant.
So, the statement that best describes leptin is: "A long-term acting hormone released from adipose tissue that binds to receptors in the hypothalamus to inhibit feeding behaviour."
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