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Where does oxidative phosphorylation primarily occur?

Question

Where does oxidative phosphorylation primarily occur?

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Solution

Oxidative phosphorylation primarily occurs in the mitochondria of a cell. Here are the steps:

  1. The process begins in the matrix of the mitochondria, where the Citric Acid Cycle produces NADH and FADH2.

  2. These molecules then transfer their electrons to the electron transport chain, which is located in the inner mitochondrial membrane.

  3. As the electrons move down the chain, they cause hydrogen ions to be pumped across the membrane, creating a gradient.

  4. The potential energy from this gradient is used to power ATP synthase, an enzyme that combines ADP and a phosphate group to form ATP.

  5. This process of using the energy from the electron transport chain to create ATP is known as oxidative phosphorylation.

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