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Choose the INCORRECT statement from the options below.Opsonization of pathogens is one of the consequences of complement activation.The classical pathway is initiated by the activation of C5 to form C5a and C5b.MB-lectin proteins bind to mannose-containing carbohydrates on pathogen surface.C3a and C5a are peptide mediators of inflammation.

Question

Choose the INCORRECT statement from the options below.Opsonization of pathogens is one of the consequences of complement activation.The classical pathway is initiated by the activation of C5 to form C5a and C5b.MB-lectin proteins bind to mannose-containing carbohydrates on pathogen surface.C3a and C5a are peptide mediators of inflammation.

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Solution

The incorrect statement is: "The classical pathway is initiated by the activation of C5 to form C5a and C5b."

The classical pathway of the complement system is actually initiated by the binding of C1q to antibodies (IgG or IgM) that are attached to the surface of a pathogen. This leads to a cascade of reactions involving several complement proteins, resulting in the formation of a membrane attack complex that can lyse the pathogen. The activation of C5 to form C5a and C5b is a part of this cascade, but it is not the initiating event.

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Similar Questions

The Alternative and Classical complement pathways differ in that ONLY the Classical pathway ____.1 pointuses the breakdown products of C3 and C5 as signals to activate other elements of the immune systemattaches proteins to the surface of pathogen that promote phagocytosisconstructs a pore with variable number of C9 moleculesresults in the breakdown of C2 and C4begins with the stabilization of the natural breakdown product of C3

Which of the following are potential outcomes following complement activation?SELECT ALL THAT APPLYGeneration of antimicrobial peptidesApoptosis of virus-infected cellsInduction of a memory response by B and T cellsOpsonization of pathogens for phagocytosisCytolysis of pathogens through formation of the membrane attack complex (MAC)Induction of an inflammatory response

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What functions can complement proteins perform?Group of answer choicesprovide immunity in response to immunizationstore "memories" of specific antigens for months or yearsbind Fc receptorscoat invading microbesattract phagocytes to the site of infectioninsert themselves into the foreign cell's plasma membraneamplify the inflammatory response

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